Randomized Study Comparing a Basal BolusWith a Basal Plus Correction Insulin Regimen for the Hospital Management ofMedical and Surgical patientsWith Type 2 Diabetes Basal Plus Trial

RESULTSdImprovement in mean daily blood glucose (BG) after the first day of therapy was similar between basal bolus and basal plus groups (P = 0.16), and both regimens resulted in a lower mean daily BG than did SSI (P = 0.04). In addition, treatment with basal bolus and basal plus regimens resulted in less treatment failure (defined as.2 consecutive BG.240 mg/dL or a mean daily BG .240 mg/dL) than did treatment with SSI (0 vs. 2 vs. 19%, respectively; P , 0.001). A BG,70 mg/dL occurred in 16% of patients in the basal bolus group, 13% in the basal plus group, and 3% in the SSI group (P = 0.02). There was no difference among the groups in the frequency of severe hypoglycemia (,40 mg/dL; P = 0.76).